Department of Microbiology and Immunobiology
Harvard Medical School
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Publications

  1. Morin B, Whelan SP. Sensitivity of the polymerase of vesicular stomatitis virus to 2' substitutions in the template and nucleotide triphosphate during initiation and elongation. J Biol Chem 2014 [Epub ahead of print]
  2. Ma Y, Wei Y, Zhang X, Zhang Y, Cai H, Zhu Y, Shilo K, Oglesbee M, Krakowka S, Whelan SP, Li J. mRNA cap methylation influences pathogenesis of vesicular stomatitis virus in vivo. J Virol 2014 88(5): 2913-26.
  3. Piccinotti S, Kirchhausen T, Whelan SP. Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin. J Virol Y2013 87(21): 11637-47.
  4. Morin B, Kranzusch PJ, Rahmeh AA, Whelan SP. The polymerase of negative-stranded RNA viruses.. Curr Opin Virol 2013 3(2): 103-10.
  5. Ivanovic T, Choi JL, Whelan SP, van Oijen AM, Harrison SC. Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates.. eLife 2013 10.7554/eLife.00333
  6. Jae LT, Raaben M, Riemersma M, van Beusekom E, Blomen VA, Velds A, Kerkhoven RM, Carette JE, Topaloglu H, Meinecke P, Lefeber DJ, Whelan SP, van Bokhoven H, Brummelkamp TR. Deciphering the glycosylome of dystroglycanopathies using haploid screens for Lassa virus entry. Science 2013 340(6131): 479-83.
  7. Semler B, Whelan SP. Methods to study RNA virus molecular biology. Methods. 2013 59: 165-6.
  8. Ivanovic T, Choi J, Whelan SP, van Oijen AM, Harrison SC. Influenza virus membrane fusion: cooperative fold-back of stochastically induced hemagglutinin intermediates. eLife 2013 10.7554/eLife.00333
  9. Lee AS, Burdeneick-Kerr R, Whelan SP. A ribosome-specialized translation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs PNAS 2013 110(1) 324-9.
  10. Krishnan A, Miller EH, Herbert AS, NG M, Ndungo E, Whelan SP, Dye JM, Chandran KC. Neimann-Pick C1 (NPC1)/NPC1-like1 Chimeras define sequences critical for NPC1’s function as a filovirus entry receptor. Viruses 2012 4:2471-248.
  11. Morin B, Whelan SPJ. La proteine L des Mononegavirales. Virologie 2012 16(4) 258-268 (in French).
  12. Rahmeh AA, Morin B, Schenk AD, Liang B, Heinrich BS, Brusic V, Walz T, Whelan SP. Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virus. PNAS 2012 109(36): 14628-33.
  13. Kranzusch P, Whelan SP. Architecture and regulation of negative-strand viral enzymatic machinery. RNA Biol. 2012 9(7): 941-8.
  14. Heinrich BS, Morin B, Rahmeh AA, Whelan SP. Structural properties of the C terminus of vesicular stomatitis virus N protein dictate N-RNA complex assembly, encapsidation, and RNA synthesis. J Virol. 2012 86(16):8720-9.
  15. Miller EH, Obernosterer G, Raaben M, Herbert AS, Deffieu MS, Krishnan A, Ndungo E, Sandesara RG, Carette JE, Kuehne AI, Ruthel G, Pfeffer SR, Dye JM, Whelan SP, Brummelkamp TR, Chandran K. Ebola virus entry requires the host-programmed recognition of an intracellular receptor. EMBO J. 2012 31(8):1947-60.
  16. Morin B, Rahmeh AA, Whelan SP. Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase. EMBO J. 2012 31(5):1320-9.
  17. Kranzusch PJ, Whelan SP. Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex. PNAS 2011 108(49):19743-8.
  18. Cureton DK, Burdeinick-Kerr R, Whelan SP. Genetic inactivation of COPI coatomer separately inhibits vesicular stomatitis virus entry and gene expression. J Virol. 2011 86(2):655-66.
  19. Mulherkar N, Raaben M, de la Torre JC, Whelan SP, Chandran K. The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway. Virology 2011 419(2): 72-83.
  20. Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Juehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SPJ, Chandran K, Brummelkamp TR. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1 Nature 2011 477(7364): 340-3.
  21. Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Akhtar N, Luo L, Whelan SPJ, Sabatini B, Cepko CL. Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. PNAS 2011 108(37): 15414-9.
  22. Stanifer ML, Cureton DK, Whelan SPJ. A recombinant vesicular stomatitis virus bearing a lethal mutation in the glycoprotein gene uncovers a second site suppressor that restores fusion. J Virol. 2011 85(16): 8105-15.
  23. Tekes G, Rahmeh AA, Whelan SPJ. A freeze frame view of vesicular stomatitis virus transcription defines a minimal length of RNA for 5' processing. PLoS Pathogens 2011 7(6): e1002073.
  24. Rahmeh AA, Schenk AD, Danek EI, Kranzusch PJ, Liang B, Walz T, Whelan SP. Molecular architecture of the vesicular stomatitis virus RNA polymerase. PNAS 2010 107(46): 20075-80.
  25. Kranzusch PJ, Schenk A, Rahmeh A, Radoshitzky SR, Bavari S, Walz T, Whelan SP. Assembly of a functional Machupo virus polymerase complex. PNAS 2010 107(46): 20069-74.
  26. Cureton DK, Massol R, Whelan SP, Kirchhausen T. Clathrin dependent endocytosis of truncated vesicular stomatitis virus particles is actin independent. PLoS Pathogens 2010 6(9): e1001127.
  27. Radoshitzky SR, Dong L, Chi X, Clester JC, Retterer C, Spurgers K, Kuhn JH, Sandwick S, Ruthel G, Kota K, Boltz D, Warren T, Kranzusch PJ, Whelan SP, Bavari S. Infectious Lassa virus, but not filoviruses, is restricted by BST-2/Tetherin. J Virol. 2010 84(20): 10569-80.
  28. Heinrich BS, Cureton DK, Rahmeh AA, Whelan SP. Protein expression redirects vesicular stomatitis virus RNA synthesis to cytoplasmic inclusions. PLoS Pathogens 2010; 6(6): e1000958.
  29. Iannacone M, Moseman EA, Tonti E, Bosurgi L, Junt T, Henrickson SE, Whelan SP, Guidotti LG, von Andrian UH. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature 2010; 465(7301): 1079-83.
  30. Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC. Peroxisomes are signaling platforms for antiviral innate immunity. Cell 2010; 141(4): 668-81.
  31. Wolf MC, Freiberg AN, Zhang T, Akyol-Ataman Z, Grock A, Hong PW, Li J, Watson NF, Fang AQ, Aguilar HC, Porotto M, Honko AN, Damoiseaux R, Miller JP, Woodson SE, Chantasirivisal S, Fontanes V, Negrete OA, Krogstad P, Dasgupta A, Moscona A, Hensley LE, Whelan SP, Faull KF, Holbrook MR, Jung ME, Lee B. A broad-spectrum antiviral targeting entry of enveloped viruses. PNAS 2010; 107(7): 3157-62.
  32. Wong AC, Sandesara RG, Mulherkar N, Whelan SP, Chandran K. A forward genetic strategy reveals destabilizing mutations in the Ebolavirus glycoprotein that alter its protease dependence during cell entry. J Virol. 2010; 84(1): 163-75.
  33. Rahmeh AA, Li J, Kranzusch PJ, Whelan SP. Ribose 2'-O methylation of the vesicular stomatitis virus mRNA cap precedes and facilitates subsequent guanine-N-7 methylation by the large polymerase protein. J Virol. 2009; 83(21): 11043-50.
  34. Cureton DK, Massol RH, Saffarian S, Kirchhausen TL, Whelan SP. Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization. PLoS Pathog. 2009; 5(4): e1000394.
  35. Li J, Rahmeh A, Brusic V, Whelan SP. Opposing effects of inhibiting cap addition and cap methylation on polyadenylation during vesicular stomatitis virus mRNA synthesis. J Virol. 2009; 83(4):1930-40.
  36. Whelan SP. Response to "Non-segmented negative-strand RNA virus RNA synthesis in vivo". Virology 2008; 371(2): 234-7.
  37. Li J, Rahmeh A, Morelli M, Whelan SP. A conserved motif in region v of the large polymerase proteins of nonsegmented negative-sense RNA viruses that is essential for mRNA capping. J Virol. 2008; 82(2): 775-84.
  38. Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, van Rooijen N, Mempel TR, Whelan SP, von Andrian UH. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 2007; 450(7166): 110-4.
  39. Wang JT, McElvain LE, Whelan SP. Vesicular stomatitis virus mRNA capping machinery requires specific cis-acting signals in the RNA. J Virol. 2007; 81(20): 11499-506.
  40. Li J, Chorba JS, Whelan SP. Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation. J Virol. 2007; 81(8): 4104-15.
  41. Li J, Wang JT, Whelan SP. A unique strategy of mRNA cap methylation used by vesicular stomatitis virus. Proc Natl Acad Sci U S A 2006: 103 8493-8.
  42. Robinson C. D., Lourido S., Whelan S. P., Dudycha J. L., Lynch M., Isern S. Viral Transgenesis of Embryonic Cell Cultures from the Freshwater Microcrustacean Daphnia. J. Exp. Zool. 2006;305A:62-67.
  43. Schott D, Cureton DK, Whelan SP, Hunter C. An antiviral role for the RNA interference machinery in Caenorhabditis elegans. Proc Natl Acad Sci U S A 2005: 102(51):18420-18424.
  44. Li J, Fontaine-Rodriguez EC, Whelan SP. Amino acid residues within conserved domain VI of the vesicular stomatitis virus large polymerase protein essential for mRNA cap methyltransferase activity. J Virol. 2005;79(21):13373-84.
  45. Chandran K, Sullivan NJ, Felbor U, Whelan SP, Cunningham JM. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science. 2005;308(5728):1643-5.
  46. Cherry S, Doukas T, Armknecht S, Whelan S, Wang H, Sarnow P, Perrimon N. Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev. 2005;19(4):445-52.
  47. Whelan SP, Barr JN, Wertz GW. Transcription and replication of nonsegmented negative-strand RNA viruses. Curr Top Microbiol Immunol. 2004;283:61-119.
  48. Barr JN, Whelan SP, Wertz GW. Transcriptional control of the RNA-dependent RNA polymerase of vesicular stomatitis virus. Biochim Biophys Acta. 2002;1577(2):337-53.
  49. Whelan SP, Wertz GW. Transcription and replication initiate at separate sites on the vesicular stomatitis virus genome. Proc Natl Acad Sci U S A. 2002;99(14):9178-83.
  50. Whelan SP, Barr JN, Wertz GW. Identification of a minimal size requirement for termination of vesicular stomatitis virus mRNA: implications for the mechanism of transcription. J Virol. 2000;74(18):8268-76.
  51. Whelan SP, Wertz GW. Regulation of RNA synthesis by the genomic termini of vesicular stomatitis virus: identification of distinct sequences essential for transcription but not replication. J Virol. 1999;73(1):297-306.
  52. Whelan SP, Wertz GW. The 5' terminal trailer region of vesicular stomatitis virus contains a position-dependent cis-acting signal for assembly of RNA into infectious particles. J Virol. 1999;73(1):307-15.
  53. Barr JN, Whelan SP, Wertz GW. cis-Acting signals involved in termination of vesicular stomatitis virus mRNA synthesis include the conserved AUAC and the U7 signal for polyadenylation. J Virol. 1997;71(11):8718-25.
  54. Barr JN, Whelan SP, Wertz GW. Role of the intergenic dinucleotide in vesicular stomatitis virus RNA transcription. J Virol. 1997;71(3):1794-801.
  55. Whelan SP, Ball LA, Barr JN, Wertz GT. Efficient recovery of infectious vesicular stomatitis virus entirely from cDNA clones. Proc Natl Acad Sci U S A. 1995;92(18):8388-92.
  56. Whelan SP, Evans D, Almond JW. Manipulation of the cellular binding properties of poliovirus: implications for non-target effects of recombinant vaccines. Dev Biol Stand. 1995;84:129-36.
  57. Wertz GW, Whelan S, LeGrone A, Ball LA. Extent of terminal complementarity modulates the balance between transcription and replication of vesicular stomatitis virus RNA. Proc Natl Acad Sci U S A. 1994;91(18):8587-91.